Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

PHASE1RecruitingINTERVENTIONAL
Enrollment

327

Participants

Timeline

Start Date

June 27, 2023

Primary Completion Date

May 30, 2029

Study Completion Date

May 30, 2029

Conditions
MSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers
Interventions
DRUG

HRO761

Tablet

BIOLOGICAL

pembrolizumab

Concentrate for solution for infusion

DRUG

irinotecan

Concentrate for solution for infusion

Trial Locations (30)

1200

RECRUITING

Novartis Investigative Site, Brussels

10002

RECRUITING

Novartis Investigative Site, Taipei

10017

RECRUITING

Memorial Sloan Kettering, New York

10032

RECRUITING

Columbia University Medical Ctr, New York

13273

RECRUITING

Novartis Investigative Site, Marseille

17176

RECRUITING

Novartis Investigative Site, Stockholm

20089

RECRUITING

Novartis Investigative Site, Rozzano

20162

RECRUITING

Novartis Investigative Site, Milan

28009

RECRUITING

Novartis Investigative Site, Madrid

28040

RECRUITING

Novartis Investigative Site, Madrid

31059

RECRUITING

Novartis Investigative Site, Toulouse

33076

RECRUITING

Novartis Investigative Site, Bordeaux

45147

RECRUITING

Novartis Investigative Site, Essen

46010

RECRUITING

Novartis Investigative Site, Valencia

77030

RECRUITING

Univ of TX MD Anderson Cancer Cntr, Houston

89081

RECRUITING

Novartis Investigative Site, Ulm

90095

RECRUITING

University of California LA, Los Angeles

94115

RECRUITING

UCSF, San Francisco

100036

RECRUITING

Novartis Investigative Site, Beijing

119228

RECRUITING

Novartis Investigative Site, Singapore

510655

RECRUITING

Novartis Investigative Site, Guangzhou

6423906

RECRUITING

Novartis Investigative Site, Tel Aviv

02215

RECRUITING

Dana Farber Cancer Institute, Boston

07740

RECRUITING

Novartis Investigative Site, Jena

277 8577

RECRUITING

Novartis Investigative Site, Kashiwa

0310

RECRUITING

Novartis Investigative Site, Oslo

03722

RECRUITING

Novartis Investigative Site, Seoul

08035

RECRUITING

Novartis Investigative Site, Barcelona

SW3 6JJ

RECRUITING

Novartis Investigative Site, London

OX3 7LE

RECRUITING

Novartis Investigative Site, Oxford

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY