CANF-Comb-II PET-MR in Atherosclerosis Multisite

RecruitingOBSERVATIONAL
Enrollment

80

Participants

Timeline

Start Date

March 21, 2023

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Carotid AtherosclerosisAsymptomatic Carotid Artery StenosisCarotid Artery Atheroma
Interventions
DRUG

64Cu-25%-CANF-Comb

Patients treated with OMT alone that are not treated with CEA will receive an intravenous injection of 4-6 mCi of 64Cu-25%-CANF-Comb radiotracer for PET/MR imaging at the initial imaging visit and at 12-18 months, or earlier if they develop symptoms. While 12-18 months is the preferred window for repeat imaging, if imaging during this time frame is not achievable, the patient may return anytime throughout the remainder of the study.

DRUG

64Cu-25%-CANF-Comb

Patients treated with OMT and CEA will receive an intravenous injection of 4-6 mCi of 64Cu-25%-CANF-Comb radiotracer for PET/MR imaging at the initial imaging visit.

Trial Locations (2)

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

63130-2344

RECRUITING

Washington University in St. Louis, St Louis

All Listed Sponsors
collaborator

Cedars-Sinai Medical Center

OTHER

collaborator

University of California, Santa Barbara

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Washington University School of Medicine

OTHER