Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

October 25, 2023

Primary Completion Date

May 15, 2026

Study Completion Date

May 15, 2026

Conditions
Locally Advanced Extraskeletal Myxoid ChondrosarcomaLocally Advanced LeiomyosarcomaLocally Advanced LiposarcomaLocally Advanced Undifferentiated Pleomorphic SarcomaLocally Advanced Unresectable Soft Tissue SarcomaMetastatic Soft Tissue SarcomaMetastatic Undifferentiated Pleomorphic SarcomaUnresectable LeiomyosarcomaUnresectable LiposarcomaUnresectable Undifferentiated Pleomorphic Sarcoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood and urine sample

DRUG

Cabozantinib

Given PO

PROCEDURE

Computed Tomography

Undergo CT

BIOLOGICAL

Ipilimumab

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

Trial Locations (27)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20007

MedStar Georgetown University Hospital, Washington D.C.

20892

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

National Institutes of Health Clinical Center, Bethesda

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

32610

University of Florida Health Science Center - Gainesville, Gainesville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

90020

Keck Medicine of USC Koreatown, Los Angeles

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

92612

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92663

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06520

Yale University, New Haven

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

All Listed Sponsors
lead

National Cancer Institute LAO

UNKNOWN

NCT05836571 - Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma | Biotech Hunter | Biotech Hunter