Adaptive RADiation Therapy with Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

April 1, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

October 31, 2027

Conditions
Localized Muscle Invasive Bladder Urothelial CarcinomaMuscle-Invasive Bladder Carcinoma
Interventions
DRUG

Sacituzumab govitecan

8 mg/kg Sacituzumab Govitecan is to be administered intravenously in 21-day cycles on Day 1 and Day 8; the next cycle should start a minimum of 14 days after the Day 8 dose (i.e., the Day 8 infusion will be counted as the first day of that 14-day period).

RADIATION

Adaptive Radiotherapy

Concurrently, participants will receive an individualized tailored plan for radiation therapy.

Trial Locations (1)

44195

RECRUITING

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Varian Inc

UNKNOWN

collaborator

Gilead Sciences

INDUSTRY

lead

Shilpa Gupta, MD

OTHER