Measuring Acute Drug Demand in Humans

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

August 8, 2023

Primary Completion Date

October 31, 2027

Study Completion Date

October 31, 2027

Conditions
Opioid Use DisorderOpioid Dependence
Interventions
DRUG

Drug A (Blinded Drug)

Participants will receive a double-blinded oral study medication as part of their daily sessions and will provide feedback regarding the effects of the medication on various measures. Though the study medications are FDA approved, they are being used here for a non-FDA approved purpose (though the FDA has provided permission to use these drugs in this study).

DRUG

Drug B (Blinded Drug)

Participants will receive a double-blinded oral study medication as part of their daily sessions and will provide feedback regarding the effects of the medication on various measures. Though the study medications are FDA approved, they are being used here for a non-FDA approved purpose (though the FDA has provided permission to use these drugs in this study).

DRUG

Drug C (Blinded Drug)

Participants will receive a double-blinded oral study medication as part of their daily sessions and will provide feedback regarding the effects of the medication on various measures. Though the study medications are FDA approved, they are being used here for a non-FDA approved purpose (though the FDA has provided permission to use these drugs in this study).

DRUG

Drug D (Blinded Drug)

Participants will receive a double-blinded oral study medication as part of their daily sessions and will provide feedback regarding the effects of the medication on various measures. Though the study medications are FDA approved, they are being used here for a non-FDA approved purpose (though the FDA has provided permission to use these drugs in this study).

DRUG

Suvorexant (20mg/day)

Double blind administration of suvorexant once per day during residential stay until discharge.

DRUG

Placebo

Double blind administration of placebo once per day during residential stay until discharge.

Trial Locations (1)

21224

RECRUITING

Behavioral Pharmacology Research Unit, Baltimore

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Johns Hopkins University

OTHER