NCT05828823View on ClinicalTrials.gov

Incremental Hemodialysis: The TwoPlus Trial

NARecruitingINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

February 26, 2024

Primary Completion Date

September 30, 2027

Study Completion Date

March 31, 2028

Conditions
End-Stage Kidney Disease
Interventions
DEVICE

Hemodialysis twice weekly

Frequency and duration of hemodialysis is tailored to the patient. Adjuvant pharmacotherapy is prescribed to maintain volume, electrolyte and acid-base homeostasis ( e.g., diuretics, sodium bicarbonate and potassium binding patiromer)

OTHER

Hemodialysis thrice weekly

Conventional hemodialysis regimen

Trial Locations (10)

10065

RECRUITING

Renal Research Institute (RRI), New York

11427

RECRUITING

Northwell Health, Queens

21218

RECRUITING

Johns Hopkins University School of Medicine (JHUSM), Baltimore

22904

RECRUITING

University of Virginia (UVA), Charlottesville

27157

RECRUITING

Atrium Health Wake Forest Baptist, Winston-Salem

27599

RECRUITING

University of North Carolina Chapel Hill, Chapel Hill

30322

RECRUITING

Emory University, Atlanta

32209

RECRUITING

University of Florida, Jacksonville

44106

RECRUITING

Cleveland Clinic, Case Western Reserve University (CWRU), Cleveland

02114

RECRUITING

Massachusetts General Hospital, Boston

All Listed Sponsors
collaborator

Patient-Centered Outcomes Research Institute

OTHER

lead

Wake Forest University Health Sciences

OTHER