Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

October 16, 2023

Primary Completion Date

June 18, 2026

Study Completion Date

June 18, 2026

Conditions
Castration-Resistant Prostate CarcinomaMetastatic Castration-Resistant Prostate CarcinomaRefractory Prostate CarcinomaStage IVB Prostate Cancer AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/MRI or PET/CT

DRUG

Tuvusertib

Given PO

PROCEDURE

Ultrasound Imaging

Undergo U/S

Trial Locations (26)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

22908

University of Virginia Cancer Center, Charlottesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

53718

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

55905

Mayo Clinic in Rochester, Rochester

62269

Memorial Hospital East, Shiloh

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75237

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

85054

Mayo Clinic Hospital in Arizona, Phoenix

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

32224-9980

Mayo Clinic in Florida, Jacksonville

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT05828082 - Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer | Biotech Hunter | Biotech Hunter