Emergency Department-Initiated Medications for Alcohol Use Disorder

PHASE3RecruitingINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

August 17, 2024

Primary Completion Date

December 1, 2027

Study Completion Date

March 1, 2028

Conditions
Alcohol Use Disorder
Interventions
DRUG

Naltrexone Pill

In the MAUD component, some participants will receive oral Naltrexone in the ED.

DRUG

Naltrexone Injection

In the MAUD component, some participants will receive a dose of XR-NTX (injection) in the ED.

BEHAVIORAL

Brief Negotiation Interview

Brief Negotiation Interview (BNI) has four key components: (1) permission to discuss substance use, (2) feedback on the health consequences of ongoing substance use, including making a connection between the ED visit and substance use, (3) motivational enhancement, and (4) negotiation and advice.

DRUG

Gabapentin Pill

In the MAUD component, ancillary treatment with gabapentin will be provided.

Trial Locations (1)

06520

RECRUITING

Yale New Haven Hospital, New Haven

All Listed Sponsors
collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

lead

Yale University

OTHER