264
Participants
Start Date
August 14, 2023
Primary Completion Date
August 31, 2025
Study Completion Date
February 28, 2027
Pulmonary arterial denervation
"Contrast pulmonary artery (PA) angiography will be performed to localize the pulmonary artery bifurcation level and calculate the PA diameter. Once the anatomy deemed acceptable, the radiofrequency ablation catheter will be introduced into ostium of the left PA and the distal bifurcation area of the main PA.~The catheter will be manoeuvred within the PA to allow energy delivery in a circumferential manner to ensure that the electrodes are tightly in contact with the endovascular surface. About three ablations at 45-55 ℃ for 120 seconds each will be performed in ostium of the left PA and the distal bifurcation area of the main PA.~For non-atrial fibrillation patients, dual antiplatelet therapy for 1 month after PADN is recommended. Patients with atrial fibrillation should continue new oral anticoagulants and patients who underwent metal valve replacement should continued oral warfarin anticoagulation according to guidelines, which could determined by the physician."
Guideline-directed medical therapy (GDMT) for heart failure
"GDMT medication recommendation including:~* Angiotensin-converting enzyme inhibitor (ACEI) or angiotensin-receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNI)~* Beta-receptor blocker (BB)~* Mineralocorticoid receptor antagonist (MRA)~* Sodium-glucose co-transporter 2 (SGLT2) inhibitor~* Diuretics~The medication regimen (type and dosage) will be the investigator's discretion in accordance with the 2023 ESC Guidelines for Heart Failure. The type and dosage of all GDMT medications (except for diuretics) should remain unchanged through follow-up duration (at 12-month visit), unless the participant's conditions need adjust of GDMT regimens. Dosage and single or combination of diuretics are all left at physician's discretion."
RECRUITING
General Hospital of Northern Theater Command, Shenyang
The General Hospital of Northern Theater Command
OTHER
The First Affiliated Hospital with Nanjing Medical University
OTHER
First Hospital of Tsinghua University
OTHER
Cangzhou Central Hospital
OTHER
Chinese Academy of Medical Sciences, Fuwai Hospital
OTHER
Guangdong Provincial People's Hospital
OTHER
The First Affiliated Hospital of Guangzhou Medical University
OTHER
First Affiliated Hospital of Harbin Medical University
OTHER
Tongji Hospital
OTHER
Second Hospital of Jilin University
OTHER
China-Japan Union Hospital, Jilin University
OTHER
Shanxi Cardiovascular Hospital
OTHER
RenJi Hospital
OTHER
Shanghai 10th People's Hospital
OTHER
Beijing Anzhen Hospital
OTHER
West China Hospital
OTHER
Sichuan Academy of Medical Sciences
OTHER
The First Affiliated Hospital of Soochow University
OTHER
TEDA International Cardiovascular Hospital
OTHER
Tianjin Medical University General Hospital
OTHER
Renmin Hospital of Wuhan University
OTHER
Zhongnan Hospital
OTHER
First Affiliated Hospital Xi'an Jiaotong University
OTHER
Xiamen Cardiovascular Hospital, Xiamen University
OTHER
Zhejiang University
OTHER
Shengjing Hospital
OTHER
First Affiliated Hospital of Fujian Medical University
OTHER
First Affiliated Hospital of Wenzhou Medical University
OTHER
Gansu Provincial Hospital
OTHER
Yanan Hospital of Kunming City
UNKNOWN
First Affiliated Hospital of Chongqing Medical University
OTHER
Huaihe Hospital of Henan University
OTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
OTHER
The First Affiliated Hospital of Nanchang University
OTHER
Hunan Provincial People's Hospital
OTHER
Tianjin Medical University Second Hospital
OTHER
First Affiliated Hospital, Sun Yat-Sen University
OTHER
The First Hospital of Jilin University
OTHER
Pulnovo Medical (Wuxi) Co., Ltd.
INDUSTRY