Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated With Experimental Influenza Virus (MK-4482-019)

PHASE1CompletedINTERVENTIONAL
Enrollment

161

Participants

Timeline

Start Date

August 21, 2023

Primary Completion Date

June 28, 2024

Study Completion Date

June 28, 2024

Conditions
Influenza Infection
Interventions
DRUG

Molnupiravir

Four molnupiravir 200 mg capsules (800 mg total dose) taken twice daily by mouth.

DRUG

Placebo molnupiravir

Four placebo capsules matched to molnupiravir taken twice daily by mouth.

DRUG

Placebo oseltamivir

Placebo capsule matched to oseltamivir taken twice daily by mouth.

DRUG

Oseltamivir

One capsule of oseltamivir 75 mg taken twice daily by mouth.

BIOLOGICAL

Influenza A Virus

Influenza A challenge virus given once by intranasal administration at an inoculum concentration of between approximately 5 and 7 Log10 tissue culture infective dose 50% (TCID50/mL).

Trial Locations (1)

E1 2AX

hVIVO Services ( Site 0001), London

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT05818124 - Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated With Experimental Influenza Virus (MK-4482-019) | Biotech Hunter | Biotech Hunter