An Open-Label, Nonrandomized, Multicenter Extension Study to Evaluate the Long-term Safety and Efficacy of Pegcetacoplan in Participants With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

May 29, 2023

Primary Completion Date

July 31, 2027

Study Completion Date

July 31, 2027

Conditions
C3GIC-MPGNC3 GlomerulopathyC3 GlomerulonephritisComplement 3 GlomerulopathyComplement 3 Glomerulopathy (C3G)Complement 3 GlomerulonephritisDense Deposit DiseaseDDDMembranoproliferative GlomerulonephritisMembranoproliferative Glomerulonephritis (MPGN)Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)
Interventions
DRUG

Pegcetacoplan

Complement (C3) Inhibitor

Trial Locations (47)

165

Ospesale Pediatrico bambino Gesu (39005), Rome

3065

St. Vincent's Hospital Melbourne (61003), Fitzroy

3080

Seoul National University Hospital (82003 & 82005), Soeul

3722

Yonsei University College of Medicine, Sinchon Severance Hospital (82002), Seoul

4102

Kidney Trials Unit, Princess Alexandra Hospital (61007), Woolloongab

8035

Hosp. Universit. Materno-Infantil Vall d' Hebron (34006), Barcelona

10032

Columbia Nephrology (01039), New York

11040

Cohen Children Hospital, Pediatric Pharmacy (01022), Hyde Park

14021

Institute for Clinical and Experimental Medicine (42001), Prague

18017

Northeast Clinical Research Center LLC (01009), Bethlehem

20122

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (39004), Milan

24020

Istituto di Ricerche Farmacologiche Mario Negri IRCCS (39003), Ranica

28041

Hospital Universitario 12 de Octubre (34008), Madrid

30322

Emory Investigational Drug Service (01021), Atlanta

32610

University of Florida, Department of Pediatric Nephrology (01010), Gainesville

33076

CHU de Bordeaux - Hopital Pellegrin (33010), Bordeaux

44093

Institut de transplantation urologie-nephrologie (33011), Nantes

46017

Hospital Universitario Dr Peset (34009), Valencia

48109

University of Michigan Hospital (01008), Ann Arbor

52242

University of Iowa Hospital and Clinics (01030), Iowa City

77030

Texas Children's Hospital (01027), Houston

80045

Children's Hospital Colorado (01037), Aurora

90022

Academic Medical Research Institute (01034), Los Angeles

97239

Oregon Health & Science Univ., Dept. Pediatrics (01038), Portland

4920235

Schneider Childrens Medical Center (97204), Petah Tikva

07601

Hackensack Meridian Health (01036), Hackensack

CPA X5016KEH

Hospital Privado-Universitario de Cordoba (54004), Córdoba

X5000

Clinica Privada Velez Sarsfield (54007), Córdoba

B-3000

Catholic University of Leuven (32001), Leuven

30150-221

Santa Casa de Misericordia de Belo Horizonte (55017), Belo Horizonte

90020-090

Irmandade da Santa Casa Misericordia Porto Alegre (55016), Porto Alegre

18618-687

HC UNESP Botucatu (55010), Botucatu

90035-903

Hospital de Clinicas de Porto Alegre (55018), Porto Alegre

52010-095

Real Hospital Portugues de Beneficencia (55015), Recife

22270-060

Ruschel Medicina E Pesquisa Clinica (55012), Rio de Janeiro

1500900-000

Hospital De Base (55014), São José do Rio Preto

04038-002

Hospital do Rim - Fundacao Oswaldo Ramos (55005), São Paulo

05403-900

Univ Sao Paulo, Av. Dr Eneas Carvalho de Aguiar, 155 (55007), São Paulo

852-8501

Nagasaki University Hospital (81005), Nagasaki

430-8558

Seirei Hamamatsu General Hospital (81004), Hamamatsu

1105 AZ

AMC Apotheek Goederenontvangst (31002), Amsterdam

9713 GZ

University Medical Center Groningen (31004), Groningen de Brug

6500 HB

Radboud University Medical Center (31003), Nijmegen

CH-1011

CHUV Lausanne (41002), Lausanne

W12 0HS

Imperial College Hammersmith Hospital (44013), London

M13 9WL

Royal Manchester Children's Hospital (44011), Manchester

NG7 2UH

Nottingham University Hospitals NHS Trust (44012), Nottingham

Sponsors
All Listed Sponsors
lead

Apellis Pharmaceuticals, Inc.

INDUSTRY