NCT05805371 - PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

July 19, 2024

Primary Completion Date

November 11, 2026

Study Completion Date

November 11, 2026

Conditions

Castration-Resistant Prostate CarcinomaMetastatic Prostate CarcinomaStage IVB Prostate Cancer AJCC v8

Interventions

BIOLOGICAL

Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes

Given IV

PROCEDURE

Biopsy

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood, stool, and urine sample collection

PROCEDURE

Bone Scan

Undergo bone scan

PROCEDURE

Computed Tomography

Undergo CT scan

RADIATION

External Beam Radiation Therapy

Undergo radiation

PROCEDURE

Leukapheresis

Undergo leukapheresis

PROCEDURE

Lymphodepletion Therapy

Undergo lymphodepletion

Trial Locations (1)

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER