Evaluation of Safety and Effectiveness of TLD Radiofrequency Ablation in the Treatment of COPD

Patients allocated to experimental group will receive TLD therapy during which radiofrequency energy will be delivered to vagus nerve surrounding airway under bronchoscopy.

Patients allocated to control group will receive sham TLD procedure during which catheter will be placed in all treatment locations with no radiofrequency energy delivered.

Patients will also receive standard of care that meet the recommendations of GOLD guideline.