Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

178

Participants

Timeline

Start Date

December 7, 2023

Primary Completion Date

November 30, 2026

Study Completion Date

November 30, 2026

Conditions
NSCLC
Interventions
DRUG

Atezolizumab

Atezolizumab will be given to participants either intravenously at a dosage of 1200mg or subcutaneously at a dosage of 1875 mg on Day 1 of each 21-day cycle for Arms A, B, and C, and on days 1 and 22 of concurrent chemoradiotherapy for Arm C only.

DRUG

Tiragolumab

Tiragolumab will be given to participants intravenously at a dosage of 600 mg on day 1 of each 21-day cycle (Arms B and C), and on days 1 and 22 of concurrent chemoradiotherapy (Arm C only).

Trial Locations (15)

13057

Hematology Oncology Associates of Central New York, P.C., East Syracuse

13210

SUNY Upstate Medical University, Syracuse

43210

Ohio State University, Columbus

53792

University of Wisconsin, Madison

60612

Rush University Medical Center, Chicago

63110

Washington University Siteman Cancer Center, St Louis

63131

Missouri Baptist Medical Center, St Louis

68198

University of Nebraska Medical Center, Omaha

92037

University of California San Diego Moores Cancer Center, La Jolla

94115

Kaiser Permanente San Francisco Medical Center, San Francisco

94589

Kaiser Permanente Vallejo Medical Center, Vallejo

94611

Kaiser Permanente Oakland Medical Center, Oakland

95051

Kaiser Permanente Santa Clara Medical Center, Santa Clara

95661

Kaiser Permanente Roseville Medical Center, Roseville

03103

New Hampshire Oncology - Hematology, PA, Manchester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Alliance Foundation Trials, LLC.

OTHER

NCT05798663 - Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC | Biotech Hunter | Biotech Hunter