500
Participants
Start Date
June 15, 2023
Primary Completion Date
July 15, 2026
Study Completion Date
June 15, 2028
Cognitive training
"Cognitive reinforcement using digital applications (PSYCARE application) during 12 weeks~+/- virtual reality based cognitive remediation application : 24 sessions over 12 weeks (only for patients who have a higher cognitive deficits (TMTB score \>110s))"
Personalized neuroprotective strategies : Vitamin B12, folinic acid, Omega 3, NAC
"Personalised neuroprotective medication adapted to the individual's biological profile :~* Vitamin B12 : 500 micrograms per day~* Folinic acid : 50 mg per day~* Omega 3 : 1380 mg EicosaPentaenoic Acid (EPA) + 1140 mg DocosaHexaenoic Acid (DHA) per day~* N-acetyl-cysteine (NAC) : 2400 mg per day~duration of supplementation(s) : 12 weeks"
Treatment as usual (TAU)
Treatment as usual (TAU), including a standardised psycho-education program with a group cognitive behavioural therapy (e.g. I\_Care - You Care) and, in FEP only, second generation antipsychotic from a restricted list (following the recommendations www.orygen.org.au)
CHRU Brest, Brest
Centre Esquirol - CHU CAEN, Caen
CHU Clermont Ferrand, Clermont-Ferrand
Centre Hospitalier La Chartreuse, Dijon
Hôpital Fontan, Lille
Hôpital La Colombière - CHU Montpellier, Montpellier
Eldorado - Maison des Adolescents de Meurthe et Moselle, Nancy
CH Orsay, Orsay
GHU Paris Neurosciences Psychiatrie, Paris
Nineteen GHU, Paris
CHU Poitiers, Poitiers
C.H. Guillaume Regnier, Rennes
CHU Purpan, Toulouse
Centre Hospitalier St Anne
OTHER