NCT05782244View on ClinicalTrials.gov

Sildenafil for Microvasculopathy in Chronic TBI

PHASE2RecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

July 2, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Traumatic Brain Injury
Interventions
DRUG

Sildenafil Citrate low dose

Sildenafil citrate 20 mg, oral, TID

DRUG

Placebo

Placebo, oral, TID

DRUG

Sildenafil medium dose

Sildenafil 40 mg, oral, TID

DRUG

Sildenafil high dose

Sildenafil 80 mg, oral, TID

Trial Locations (1)

19104

RECRUITING

University of Pennsylvania, Philadelphia

All Listed Sponsors
collaborator

Walter Reed National Military Medical Center

FED

lead

University of Pennsylvania

OTHER