Study of MB-102 (Relmapirazin) and the Use of the MediBeacon® Transdermal GFR Measurement System Using the TGFR Reusable Sensor With Disposable Adhesive Ring

PHASE3CompletedINTERVENTIONAL
Enrollment

149

Participants

Timeline

Start Date

March 20, 2023

Primary Completion Date

April 15, 2024

Study Completion Date

April 15, 2024

Conditions
Kidney DiseasesKidney InjuryKidney Failure
Interventions
DRUG

MB-102

18.6 mg/mL in a 7.0 mL volume administered by intravenous injection over 30 - 60 seconds, followed by a 10 mL normal saline flush administered intravenously over 30 - 60 seconds

DEVICE

MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)

On treatment day, participants had the TGFR reusable sensor with disposable adhesive ring placed on their chest, and the MediBeacon® Transdermal GFR Measurement System was initiated to collect background fluorescence. When this was completed, participants received a single dose of MB-102. Fluorescent measurements were collected for 12-24 hours. For those with significant renal compromise, fluorescent measurements were continued until the sensor no longer detected MB-102 in the body.

Trial Locations (5)

43213

Centricity Research, Columbus

60643

Research by Design, LLC, Chicago

78212

Clinical Advancement Center, PLLC, San Antonio

78240

Endeavor Clinical Trials, LLC, San Antonio

78744

PPD, Austin

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MediBeacon

INDUSTRY