NCT05775159 - Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer | Biotech Hunter

Enrollment

260

Participants

Timeline

Start Date

April 24, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 14, 2026

Conditions

Hepatocellular CarcinomaBiliary Tract Cancer

Interventions

DRUG

Volrustomig

CTLA-4/Anti-PD-1 Bispecific Antibody

DRUG

Bevacizumab

15 mg/kg, IV (in the vein) on day 1 of each 21 day cycle. Number of Cycles: until disease progression or unacceptable toxicity develops.

DRUG

Lenvatinib

Daily use per oral (8 mg capsules/day for participants \< 60 kg or 12 mg/day for participants ≥ 60 kg) of 21 day cycle. Number of Cycles: until disease progression or unacceptable toxicity develops.

DRUG

Rilvegostomig

anti- PD-1 and TIGIT bispecific antibody

DRUG

Gemcitabine

1000 mg/m2, IV infusion

DRUG

Cisplatin

25 mg/m2, IV infusion

Trial Locations (61)

333

RECRUITING

Research Site, Taoyuan District

736

RECRUITING

Research Site, Liuying

833

RECRUITING

Research Site, Kaohsiung City

8035

RECRUITING

Research Site, Barcelona

10002

RECRUITING

Research Site, Taipei

10065

RECRUITING

Research Site, New York

11259

RECRUITING

Research Site, Taipei

20089

RECRUITING

Research Site, Rozzano

20132

RECRUITING

Research Site, Milan

22031

WITHDRAWN

Research Site, Fairfax

28007

RECRUITING

Research Site, Madrid

28040

RECRUITING

Research Site, Madrid

31008

RECRUITING

Research Site, Pamplona

33140

WITHDRAWN

Research Site, Miami Beach

35233

RECRUITING

Research Site, Birmingham

40705

RECRUITING

Research Site, Taichung

46311

WITHDRAWN

Research Site, Dyer

50134

RECRUITING

Research Site, Florence

66103

RECRUITING

Research Site, Kansas City

70403

RECRUITING

Research Site, Tainan City

75251

WITHDRAWN

Research Site, Dallas

80131

RECRUITING

Research Site, Napoli

80756

RECRUITING

Research Site, Kaohsiung City

90089

RECRUITING

Research Site, Los Angeles

92627

WITHDRAWN

Research Site, Costa Mesa

92868

RECRUITING

Research Site, Orange

100050

RECRUITING

Research Site, Beijing

100142

RECRUITING

Research Site, Beijing

101100

RECRUITING

Research Site, Beijing

150081

RECRUITING

Research Site, Harbin

200032

RECRUITING

Research Site, Shanghai

230001

NOT_YET_RECRUITING

Research Site, Hefei

230022

RECRUITING

Research Site, Hefei

230601

RECRUITING

Research Site, Hefei

330006

WITHDRAWN

Research Site, Nanchang

350007

RECRUITING

Research Site, Fuzhou

400030

RECRUITING

Research Site, Chongqing

450008

WITHDRAWN

Research Site, Zhengzhou

510060

RECRUITING

Research Site, Guangzhou

510515

RECRUITING

Research Site, Guangzhou

530021

RECRUITING

Research Site, Nanning

610000

RECRUITING

Research Site, Chengdu

610041

RECRUITING

Research Site, Chengdu

710038

WITHDRAWN

Research Site, Xi'an

999077

RECRUITING

Research Site, Hong Kong

NOT_YET_RECRUITING

Research Site, Hong Kong

Unknown

WITHDRAWN

Research Site, Shandong

00000

RECRUITING

Research Site, Shatin

104-0045

RECRUITING

Research Site, Chūōku

277-8577

RECRUITING

Research Site, Kashiwa

241-8515

RECRUITING

Research Site, Yokohama

463-712

RECRUITING

Research Site, Seongnam-si

03080

RECRUITING

Research Site, Seoul

03722

RECRUITING

Research Site, Seoul

05505

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08036

RECRUITING

Research Site, Barcelona

CB2 0QQ

RECRUITING

Research Site, Cambridge

EH4 2XU

WITHDRAWN

Research Site, Edinburgh

NW3 2QG

RECRUITING

Research Site, London

M20 4BX

RECRUITING

Research Site, Manchester