A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen

PHASE2CompletedINTERVENTIONAL
Enrollment

285

Participants

Timeline

Start Date

March 13, 2023

Primary Completion Date

January 15, 2025

Study Completion Date

January 15, 2025

Conditions
Hypertension
Interventions
DRUG

Placebo

Placebo once daily for 12 weeks

DRUG

lorundrostat Dose 1

lorundrostat Dose 1 once daily for 12 weeks

DRUG

lorundrostat Dose 2

lorundrostat Dose 1 once daily for 4 weeks then lorundrostat Dose 2 once daily for 8 weeks for subjects who meet prespecified criteria

Trial Locations (104)

10032

Columbia University, New York

11415

Marian David, MD, PC (Elligo Health Research), New York

12203

Albany Medical College Div of Community Endocrinology, Albany

14215

University of Buffalo, Buffalo

19044

AMS Cardiology, Horsham

19104

University of Pennsylvania, Philadelphia

22015

Burke Internal Medicine, Burke

22911

Charlottesville Medical Research, Charlottesville

23435

Centricity Research (IACT Health) (Hampton Roads Center For Clinical Research, Inc.)) - Suffolk Multispecialty Research, Suffolk

23510

Eastern Virginia Medical School, Norfolk

27205

Triad Internal Medicine, Asheboro

27710

Duke University Medical Center Heart Center Clinical Research Unit, Durham

27834

East Carolina University (ECU) Physicians - East Carolina Heart Institute - East Carolina University Location, Greenville

28557

Lucas Research, Inc., New Bern

28677

Iredell Memorial Hospital, Inc (Elligo Health Research), Statesville

28803

Asheville Clinical Trials (Elite Clinical Network), Ashville

29405

Coastal Carolina Research Center, North Charleston

29414

WR- Notus Clinical Trials, LLC, Charleston

29621

Accelerated Enrollment Solutions (AES)- Anderson, Anderson

30030

Accel Research Sites, Decatur

30044

Georgia Clinical Research, LLC, Lawrenceville

30092

Alta Pharmaceutical Research Center, Peachtree Corners

30269

Randomize Now, Peachtree City

30901

Nephrology Associates, PC - Downtown Augusta, Augusta

31406

Fellows Research Alliance, Inc, Savannah

32127

Progressive Medical Research, Port Orange

32256

Clinical Neuroscience Solutions, Inc (Jacksonville), Jacksonville

32801

Clinical Neuroscience Solutions, INC., Orlando

32960

The Pierone Research Institute (Elligo Health Research), Vero Beach

33012

Indago Research & Health Center, Inc., Hialeah

33026

Patron Medical - Andres Patron D.O. (Patron Ventures, LLC), Pembroke

33176

Reserka, LLC, Miami

33186

Nuovida Research Center Corp, Miami

33606

Clinical Research of West Florida, Inc., Tampa

35211

Cardiology, P.C. - Birmingham, Birmingham

35294

University of Alabama at Birmingham (UAB) - Vascular Biology and Hypertension Program, Birmingham

37232

Vanderbilt University Medical Center (VUMC), Nashville

37404

Chattanooga Medical Research, Chattanooga

38115

Lifedoc Research, Memphis

38119

Clinical Neuroscience Solutions, Inc, Memphis

40383

Versailles Family Medicine, Versailles

40503

The Research Group of Lexington, LLC, Lexington

42001

Advanced Internal Medicine, PLLC (Elligo Health Research), Paducah

43016

Centricity Research (Aventiv Research) - Women's Health, Dublin

44195

Cleveland Clinic, Cleveland

44718

Diabetes and Endocrinology Associates of Stark County, Inc., Canton

45066

STAT Research, Springboro

45245

Intrepid Research, Cincinnati

45431

Research Innovations (Elligo Health Research), Beavercreek

46237

Franciscan Physician Network-Indiana Heart Physicians, Indianapolis

46410

Indiana Clinical Research, Merrillville

58104

Lillestol Research LLC, Fargo

60621

Eagle Clinical Research, Chicago

60637

The University of Chicago Medicine, Chicago

60805

GenHarp Clinical Solutions, Evergreen Park

62702

Southern Illinois School of Medicine, Springfield

63104

Saint Louis University, St Louis

68114

Quality Clinical Research Inc. (QCR) - Omaha, Omaha

70808

Pennington Biomedical Research Center, Baton Rouge

71301

Cambridge Clinical Trials, Alexandria

75006

Punzi Medical Center, Carrollton

75024

ACRC Trials, Plano

75075

Clinical Investigations of Texas (CIT), Plano

75149

PRX Research - Mesquite, Mesquite

75462

Medical Colleagues of Texas, LLP (Elligo Health Research), Paris

77030

Houston Methodist Research Institute, Houston

77040

Juno Research LLC, Houston

77070

Gulf Coast Clinical Research, Houston

77450

Medical Colleagues of Texas, LLP (Elligo Health Research), Katy

77479

Sugar Lakes Family Practice (Elligo Health Research), Sugar Land

77494

Synergy Groups Medical - Bissonet Site, Katy

78215

Sun Research Institute (SRI) - San Antonio, San Antonio

78240

San Antonio Clinical Trials, San Antonio

78704

Elligo Health Research, Austin

79905

David Turbay, MD, PLLC (Elligo Health Research), El Paso

80918

Delta Waves, Inc., Colorado Springs

84108

The University of Utah, Salt Lake City

85213

Brown Road Family Medicine, Mesa

85224

Chandler Clinical Trials, Chandler

85260

Scottsdale Clinical Trials (Elite Clinical Network), Scottsdale

85383

Fiel Family & Sports Medicine, Tempe

85704

Noble Clinical Research, Tucson

85715

Del Sol Research Management, LLC, Tuscon

89030

Las Vegas Clinical Trials, Las Vegas

89052

Henderson Clinical Trials, Henderson

89121

Oasis Clinical Trials, Las Vegas

89502

Renown Regional Medical Center, Reno

90048

Cedars-Sinai Medical Center, Los Angeles

91325

Northridge Clinical Trials, Northridge

91763

Catalina Research Institute, Montclair

92037

University of California San Diego (UCSD) - Altman Clinical and Translational Research Institute (ACTRI), La Jolla

92081

Blue Coast Research Center, Vista

92083

Accelerated Enrollment Solutions (AES)- Vista, Vista

92108

Triwest Research Associates, San Diego

92647

Marvel Clinical Research, Huntington Beach

92868

University of California Irvine Medical Center, Orange

93720

The Medical Research Group Inc., Fresno

95117

San Jose Clinical Trials, San Jose

95648

Clinical Trials Research, Lincoln

97404

Williamette Valley Clincial Studies, Eugene

06517

CMR of Greater New Haven, Hamden

02131

Boston Clinical Trials, Boston

01844

ActivMed Practices & Research, LLC, Methuen

03801

Seacoast Kidney & Hypertension Specialist, Portsmouth

Sponsors
All Listed Sponsors
lead

Mineralys Therapeutics Inc.

INDUSTRY

NCT05769608 - A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen | Biotech Hunter | Biotech Hunter