Potentiated Aminoglycosides in Postoperative Urinary Tract Infection Prophylaxis

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

January 16, 2024

Primary Completion Date

October 15, 2025

Study Completion Date

April 15, 2026

Conditions
Urinary Tract InfectionsUrological System Complication of Procedure
Interventions
COMBINATION_PRODUCT

mannitol-enhanced aminoglycoside

"Preselected patients with ureteral stents in situ who are scheduled to undergo endourological ureteral stent manipulation will have routine urine cultures prior to intervention.~Procedures: Consented patients will be randomized for the type of antibiotic prophylaxis according to a global randomization list (i.e. CRO, AMK, AMK1/2+MAN)).~Antibiotics (± mannitol) will be delivered in a single infusion that will be administered within 30 minutes."

DRUG

Ceftriaxon

"Preselected patients with ureteral stents in situ who are scheduled to undergo endourological ureteral stent manipulation will have routine urine cultures prior to intervention.~Procedures: Consented patients will be randomized for the type of antibiotic prophylaxis according to a global randomization list (i.e. CRO, AMK, AMK1/2+MAN)).~Antibiotics will be delivered in a single infusion that will be administered within 30 minutes."

DRUG

Amikacin

Preselected patients with ureteral stents in situ who are scheduled to undergo endourological ureteral stent manipulation will have routine urine cultures prior to intervention.

Trial Locations (1)

1011

RECRUITING

CHUV, Lausanne

All Listed Sponsors
collaborator

Ecole Polytechnique Fédérale de Lausanne

OTHER

collaborator

Insel Gruppe AG, University Hospital Bern

OTHER

lead

Centre Hospitalier Universitaire Vaudois

OTHER