Helping Osteoarthritis Patients to Walk With NSAID

PHASE4RecruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

December 14, 2023

Primary Completion Date

July 1, 2025

Study Completion Date

November 1, 2025

Conditions
Osteoarthritis, KneeOsteoarthritis, HipChronic Pain
Interventions
DRUG

therapeutic program including intermittent drug intake and multimodal rehabilitation program

"The prescribed NSAID molecule shall be chosen according to the patient's risk profile:~* gastric/duodenal risk: age \>65, history of ulcer with remission, history of inflammatory event, current low-dose acetylsalicylic acid treatment ;~* cardiovascular risk (according to Agostino scale \& SCORE);~The molecule with therefore be:~* no risk: niflumic acid, 250 mg per intake;~* gastric/duodenal risk only: diclofenac, 50-100 mg per intake, plus lansoprazole;~* cardiovascular risk only: ketoprofen, 50-100 mg per intake;~* double risk: ibuprofen, 200-400 mg per intake, plus lansoprazole. For the walk test, the highest dose of diclofenac or ketoprofen will be used. Then, the patient will be free to half the dose if pain relief is achieved so.~One gram of acetaminophen will be added to any NSAID intake. The number of intakes will be limited to twice a day (morning and evening) and to 10 times a week."

Trial Locations (1)

Unknown

RECRUITING

CHU Clemront-Ferrand, Clermont-Ferrand

All Listed Sponsors
collaborator

Plateforme d'Investigation Clinique, INSERM CIC1405, CHU de Clermont-Ferrand, France

UNKNOWN

collaborator

Fondation Apicil

OTHER

collaborator

Médecine Physique et Réadaptation, CHU de Clermont-Ferrand, France

UNKNOWN

collaborator

Médecine du Sport et Explorations Fonctionnelles, CHU de Clermont-Ferrand, France

UNKNOWN

collaborator

Rhumatologie, CHU de Clermont-Ferrand, France

UNKNOWN

collaborator

Direction de la Recherche Clinique et des Innovations, CHU de Clermont-Ferrand, France

UNKNOWN

collaborator

SARL BOUCHARENC, Saint-Chély d'Apcher, France

UNKNOWN

collaborator

"Inserm U1107 Neuro-Dol , Clermont-Ferrand, France"

UNKNOWN

collaborator

Université Clermont-Auvergne, France

UNKNOWN

lead

University Hospital, Clermont-Ferrand

OTHER