NCT05757310View on ClinicalTrials.gov

A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia

PHASE1RecruitingINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

November 15, 2024

Primary Completion Date

June 18, 2027

Study Completion Date

June 18, 2027

Conditions
Recurrent Severe Aplastic AnemiaRefractory Severe Aplastic Anemia
Interventions
BIOLOGICAL

Anti-Thymocyte Globulin

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Marrow Aspirate

Undergo bone marrow aspirate

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow biopsy

DRUG

Cyclophosphamide

Given PO and IV

PROCEDURE

Haploidentical Hematopoietic Cell Transplantation

Undergo CD4+ T-cell depleted haploHCT

DRUG

Pentostatin

Given IV

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (1)

91010

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER