Study to Assess Effect of Next-Generation Propellant MDI on Mucociliary Clearance Vs. HFA Propellant MDI in Healthy Participants

PHASE3CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

June 14, 2023

Primary Completion Date

July 22, 2024

Study Completion Date

July 22, 2024

Conditions
Mucociliary Clearance
Interventions
DRUG

HFO-1234ze(E)

"* Dose formulation: metered dose inhaler (MDI)~* Unit dose strength(s): Experimental (propellant only)~* Dosage level(s): 6 inhalations, BID~* Route of administration: Oral inhalation~* Participants will receive treatment A in 1 of 2 possible treatment sequences: AB or BA"

DRUG

HFA-134a

"* Dose formulation: metered dose inhaler (MDI)~* Unit dose strength(s): Reference (propellant only)~* Dosage level(s): 6 inhalations, BID~* Route of administration: Oral inhalation~* Participants will receive treatment B in 1 of 2 possible treatment sequences: AB or BA."

Trial Locations (5)

15213

Research Site, Pittsburgh

21287

Research Site, Baltimore

27599

Research Site, Chapel Hill

66160

Research Site, Kansas City

G4 0SF

Research Site, Glasgow

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY