Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery

PHASE3RecruitingINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

June 22, 2023

Primary Completion Date

May 31, 2025

Study Completion Date

June 30, 2025

Conditions
Antibiotic ProphylaxisColorectal Surgery
Interventions
DRUG

Loading bolus of cefoxitin

Cefoxitin \[2g\] before incision

DRUG

Intermittent cefoxitin

Additional bolus of cefoxitin \[1g\] every 2 hours until the end of surgical closure

DRUG

Continuous infusion of placebo

Continuous infusion of placebo from the end of the loading bolus until the end of surgical closure

DRUG

Continuous infusion of cefoxitin

Continuous infusion of cefoxitin \[0.5g/h\] from the end of the loading bolus until the end of surgical closure

DRUG

Intermittent placebo

Additional bolus of placebo every 2 hours until the end of surgical closure

Trial Locations (19)

86021

RECRUITING

Centre Hospitalier de Poitiers, Poitiers

Unknown

RECRUITING

CHU Angers, Angers

RECRUITING

Hopital privé Arras les Bonnettes, Arras

RECRUITING

CHU Caen, Caen

RECRUITING

CHU Clermont Ferrand, Clermont-Ferrand

RECRUITING

CHU Grenoble, Grenoble

RECRUITING

Centre Léon Bérard, Lyon

RECRUITING

Hospices Civils Lyon, Lyon

RECRUITING

Institut Paoli Calmettes, Marseille

RECRUITING

CHRU Nancy, Nancy

RECRUITING

CHU de Nantes, Nantes

RECRUITING

Hopital Européen Gorges Pompidou, Paris

RECRUITING

Clinique Mutualiste la Sagesse, Rennes

RECRUITING

Hôpital Privé Rennais Cesson Sevigné, Rennes

RECRUITING

CH St Brieuc, Saint-Brieuc

RECRUITING

CHU St Etienne, Saint-Etienne

RECRUITING

Hopitaux de Strasbourg, Strasbourg

RECRUITING

CHU Toulouse Rangueil, Toulouse

RECRUITING

CH Bretagne Atlantique vannes, Vannes

All Listed Sponsors
lead

Poitiers University Hospital

OTHER