A Study to Evaluate the Safety and Immunogenicity of a Single Dose of H1ssF-3928 mRNA-LNP in Healthy Adults

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 5, 2023

Primary Completion Date

December 4, 2025

Study Completion Date

December 4, 2025

Conditions
Influenza
Interventions
BIOLOGICAL

Influenza Virus Quadrivalent Inactivated Vaccine

A seasonal quadrivalent inactivated influenza vaccine (IIV4), prepared from influenza viruses propagated in embryonated chicken eggs, protecting against 2 influenza A subtypes and 2 influenza B subtypes.

OTHER

Sodium Chloride, 0.9%

0.9% Sodium Chloride Injection

BIOLOGICAL

VRC-FLUNPF099-00-VP (H1ssF_3928)

The vaccine consists of modified nucleoside messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNP), comprised of four lipid components: (ALC-307 (ionizable lipid), DSPC, cholesterol, and ALC-0159 \[PEG lipid\]).

Trial Locations (1)

27704

Duke Vaccine and Trials Unit, Durham

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH