A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN)

PHASE3CompletedINTERVENTIONAL
Enrollment

204

Participants

Timeline

Start Date

March 10, 2023

Primary Completion Date

October 7, 2024

Study Completion Date

August 13, 2025

Conditions
Prurigo
Interventions
DRUG

Ruxolitinib Cream

Ruxolitinib cream 1.5% twice daily (BID) during the vehicle controlled (DBVC)and open label treatment period (OLE).

DRUG

Vehicle Cream

Ruxolitinib matching vehicle cream 1.5% twice daily (BID) during the vehicle controlled period (DBVC).

Trial Locations (71)

14004

Hospital Universitario Reina Sofia, Córdoba

15706

Complejo Hospitalario Universitario de Santiago, Santiago de Compostela

19462

Dermatology Associates of Plymouth Meeting, Plymouth Meeting

20850

Dermatology Associates Pc, Rockville

24105

Universitatsklinikum Schleswig Holstein, Kiel

25123

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili), Brescia

27157

Wake Forest University, Winston-Salem

28223

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón

29425

Medical University of South Carolina, Charleston

29609

Hospital Morvan, Brest

37130

International Clinical Research Tennessee Llc, Murfreesboro

42270

University Hospital of Saint Etienne, Saint-Etienne

44093

Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu, Nantes

44106

University Hospitals Cleveland Medical Center, Cleveland

45219

UC Health, Llc, Cincinnati

46940

Hospital de Manises, Manises

48084

Revival Research Institute, Llc Troy, Troy

48346

Clarkston Medical Group, Clarkston

48455

Fachklinik Bad Bentheim Dermatologie, Bad Bentheim

52074

University Medical Center Rwth Aachen, Aachen

55131

Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii, Mainz

58453

Hautarztpraxis Dr. Med. Matthias Hoffmann, Witten

60123

Ospedali Riuniti Di Ancona, Torrette

64506

Medisearch Clinical Trials, Saint Joseph

67100

Asl 1 Avezzano L'Aquila Sulmona- Ospedale Regionale San Salvatore, Coppito

72076

Universitats-Hautklink Tubingen, Tübingen

72916

Johnson Dermatology, Fort Smith

73071

Central Sooner Research, Norman

75034

North Texas Center For Clinical Research Ntccr, Frisco

77598

Center For Clinical Studies, Webster

78660

Austin Institute For Clinical Research Aicr Pflugerville, Pflugerville

80131

Azienda Ospedaliera Universitaria Policlinico 'Federico Ii', Napoli

85006

Medical Dermatology Specialists Phoenix, Phoenix

92160

Hospital Prive D'Antony, Antony

92708

First Oc Dermatology, Fountain Valley

95123

Azienda Ospedaliero Universitaria Policlinico G.Rodolico San Marco, Catania

99204

Premier Clinical Research, Spokane

5090000

Clinical Research Chile Spa., Valdivia

7580206

Centro Medico Skinmed, Las Condes

8420383

Ciec - Centro Internacional de Estudios Cli-Nicos, Santiago

01012

Conexa Investigacion Clinica S.A., Buenos Aires

01125

Cedic Centro de Investigaciones Clinicas, Ciudad Autonoma Buenos Aires

C1055AAO

Buenos Aires Skin, Ciudad Autonoma Buenos Aires

C1425DKG

Psoriahue-Medicina Interdisciplinar, Ciudad Autonoma Buenos Aires

B7600FYK

Centro de Investigaciones Medicas Mar Del Plata, Mar del Plata

05500

Fundacion Scherbovsky, Mendoza

S2000KPG

Instituto de Especialidades de La Salud Rosario, Rosario

T4000AXL

Centro de Investigaciones Medicas Tucuman, San Miguel de Tucumán

01070

Ulb Hospital Erasme, Brussels

01200

Cliniques Universitaires Ucl Saint-Luc, Brussels

09000

Az Sint-Lucas, Ghent

Universitair Ziekenhuis Gent, Ghent

03000

Universitair Ziekenhuis (Uz) Leuven, Leuven

04000

Centre Hospitalier Universitaire de Liege - Sart Tilman, Liège

05000

Chu Ucl Namur de Saint Elisabeth, Namur

T3E 0B2

Beacon Dermatology, Calgary

L4M 1G7

Simcomed Health Ltd, Barrie

N6H 5L4

Dermeffects, London

M3H 5Y8

Research Toronto, Toronto

G1W 4R4

Centre de Recherche Saint-Louis, Québec

01307

Universitaetsklinikum Carl Gustav Carus Tu Dresden, Dresden

00137

Fondazione Policlinico Universitario Agostino Gemelli Irccs, Roma

1105 AZ

Amsterdam University Medical Centre, Amsterdam

4624 VT

Bravis Ziekenhuis, Bergen op Zoom

30-510

Pratia McM Krakow, Krakow

90-302

ETG LODZ, Lodz

35-055

Kliniczny Szpital Wojewodzki Nr 1, Rzeszów

01-142

Clinical Research Group Sp. Z.O.O, Warsaw

01-817

High-Med Przychodnia Specjalistycza, Warsaw

02-507

Centralny Szpital Kliniczny Mswia, Warsaw

03010

Hospital General Unviersitario de Alicante, Alicante

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY

NCT05755438 - A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN) | Biotech Hunter | Biotech Hunter