NCT05746546View on ClinicalTrials.gov

Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 15, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2026

Conditions
Depressive Disorder
Interventions
DRUG

Transdermal Nicotine patch

Participants will wear nicotine transdermal patches daily for 12-15 weeks. Participants will apply a study patch each morning and remove at bedtime. Active dose will titrate up from 3.5mg to 7mg, and then can optionally be further titrated to a maximum dose of 14mg. After week12, the dose will be slowly tapered over 2-3 weeks.

Trial Locations (1)

37212

RECRUITING

Vanderbilt Psychiatric Hospital, Nashville

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Vanderbilt University Medical Center

OTHER