Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

October 27, 2023

Primary Completion Date

April 30, 2027

Study Completion Date

January 31, 2030

Conditions
Unmethylated Glioblastoma
Interventions
BIOLOGICAL

Personalized Neoantigen DNA vaccine

The sites of immunization may be rotated for each of the immunizations.

BIOLOGICAL

Retifanlimab

Retifanlimab will be supplied by Incyte.

DEVICE

TDS-IM v 2.0 electroporation device

Each DNA vaccination will be 1 mL vaccine administered intramuscularly using an integrated electroporation administration system

Trial Locations (1)

63110

RECRUITING

Washington University School of Medicine, St Louis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Incyte Corporation

INDUSTRY

collaborator

PapiVax Biotech, Inc.

OTHER

collaborator

The Foundation for Barnes-Jewish Hospital

OTHER

lead

Washington University School of Medicine

OTHER