Nabilone for Agitation in Frontotemporal Dementia

PHASE2RecruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

March 7, 2023

Primary Completion Date

April 30, 2026

Study Completion Date

May 31, 2026

Conditions
Frontotemporal DementiaFrontotemporal Dementia, Behavioral VariantPrimary Progressive AphasiabvFTDPPAFTD
Interventions
DRUG

Nabilone

Nabilone is a synthetic cannabinoid that has shown benefit for agitation in Alzheimer's disease. Nabilone further has potentially beneficial properties on oxidative stress and inflammation in neurodegenerative diseases, mechanisms that have been linked to the pathophysiology of frontotemporal dementia.

DRUG

Placebo

The placebo is a capsule identical to the nabilone capsules that will be used in this clinical trial.

Trial Locations (7)

V6Z1Y6

RECRUITING

University of British Columbia, St Paul's Hospital, Vancouver

2P6H+GJ

NOT_YET_RECRUITING

Brain and Mind Institute, University of Western Ontario, London

M4N3M5

RECRUITING

Sunnybrook Health Sciences Centre, Toronto

M6A2E1

ACTIVE_NOT_RECRUITING

Baycrest Hospital, University of Toronto, Toronto

MH3V+9R

RECRUITING

Western Hospital - University of Toronto, Toronto

G1V0A6

RECRUITING

CHU de Québec, Université Laval, Laval

H4H1R3

RECRUITING

The Douglas Research Centre, Montreal

All Listed Sponsors
collaborator

Alzheimer's Drug Discovery Foundation

OTHER

lead

Simon Ducharme, MD

OTHER