Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

February 13, 2023

Primary Completion Date

February 13, 2026

Study Completion Date

February 13, 2027

Conditions
Type 1 DiabetesDiabetes Mellitus, Type 1
Interventions
DRUG

Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®)

Abatacept injected subcutaneously once per week and nasal insulin inhaled for 10 consecutive days initially and twice per week thereafter

DRUG

Abatacept (CTLA4-Ig) and nasal placebo (0.9% sodium chloride)

Abatacept injected subcutaneously once per week and nasal placebo inhaled for 10 consecutive days initially and twice per week thereafter

Trial Locations (6)

2145

The Children's Hospital at Westmead, Westmead

3050

The Royal Melbourne Hospital, Parkville

3052

The Royal Children's Hospital, Parkville

4101

Queensland Children's Hospital, South Brisbane

5006

Women's and Children's Hospital, North Adelaide

6009

Perth Children's Hospital, Nedlands

Sponsors
All Listed Sponsors
collaborator

National Health and Medical Research Council, Australia

OTHER

collaborator

Juvenile Diabetes Research Foundation

OTHER

lead

Melbourne Health

OTHER