Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 1, 2023

Primary Completion Date

November 30, 2027

Study Completion Date

November 30, 2027

Conditions
Primary Progressive AphasiaDementiaDementia, FrontotemporalAlzheimer DiseaseNeurodegenerative DiseasesFrontotemporal Lobar DegenerationApraxia, MotorDysarthriaCommunication DisordersLanguage DisordersSpeech DisordersNeurocognitive DisordersAphasiaBilingual Aphasia
Interventions
BEHAVIORAL

Video-Implemented Script Training for Aphasia (VISTA)

Participants with nonfluent/agrammatic variant primary progressive aphasia (PPA) or a predominantly nonfluent profile work on producing personally relevant scripts of 4-6 sentences in length. Length and complexity of scripts are individually tailored. The participant completes two (one hour each) teletherapy sessions per week with a clinician targeting clear and accurate script production, script memorization, and conversational usage of scripts. The participant completes 30 minutes of independent, computer-based practice 5-7 times per week, during which they speak in unison with a video/audio model of a healthy speaker clearly articulating the scripts.

BEHAVIORAL

Lexical Retrieval Training (LRT)

Participants with logopenic variant PPA, participants with semantic variant PPA, and participants with a predominantly anomic profile will work on producing spoken and written names of personally relevant target items using a self-cueing hierarchy. Treatment focuses on the use of strategies that capitalize on spared cognitive-linguistic abilities to support word retrieval. The participant completes two (one hour each) teletherapy sessions per week with a clinician plus 30 minutes of additional independent, computer-based practice exercises 5-7 times per week.

Trial Locations (3)

78752

RECRUITING

University of Texas at Austin, Austin

08025

RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08036

NOT_YET_RECRUITING

Hospital Clínic de Barcelona, Barcelona

All Listed Sponsors
collaborator

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

OTHER

collaborator

Hospital Clinic of Barcelona

OTHER

lead

University of Texas at Austin

OTHER