A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox

PHASE2CompletedINTERVENTIONAL
Enrollment

450

Participants

Timeline

Start Date

March 22, 2023

Primary Completion Date

August 28, 2024

Study Completion Date

August 28, 2024

Conditions
Monkeypox
Interventions
BIOLOGICAL

JYNNEOS

JYNNEOS is FDA-approved and licensed as a smallpox and monkeypox vaccine in the United States. JYNNEOS is a live vaccine produced from the strain Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN), an attenuated, non-replicating orthopoxvirus.

Trial Locations (18)

15213

UPMC University Center, Pittsburgh

19146

Children's Hospital of Philadelphia, Philadelphia

20037

George Washington University Medical Faculty Associates, Washington D.C.

27703

Duke Vaccine and Trials Unit, Durham

37212

Vanderbilt University Medical Center, Nashville

35233-0011

Children's of Alabama Child Health Research Unit (CHRU), Birmingham

30322-1014

Emory University School of Medicine, Atlanta

21201-1509

University of Maryland, School of Medicine, Center for Vaccine Development and Global Health, Baltimore

20892-1504

NIH Clinical Research Center, Investigational Drug Management and Research Section, Bethesda

02115-6110

Brigham and Women's Hospital, Boston

63104-1015

Saint Louis University Center for Vaccine Development, St Louis

63110-1010

Washington University in St. Louis, St Louis

14642-0001

University of Rochester Medical Center, Rochester

45229-3039

Cincinnati Children's Hospital Medical Center Vaccine Research Center, Cincinnati

77555-0435

University of Texas Medical Branch, Galveston

77030-3411

Baylor College of Medicine, Houston

98101-1466

Kaiser Permanente Washington Health Research Institute, Seattle

00716

Ponce Medical School Foundation Inc., CAIMED Center, Ponce

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH