50
Participants
Start Date
February 10, 2023
Primary Completion Date
August 30, 2026
Study Completion Date
January 30, 2028
Paclitaxel
Paclitaxel 175 mg/m2 IV
Carboplatin
Carboplatin AUC 5-6 IV
Bevacizumab
BEV 15 mg/kg IV administration will be included with each cycle EXCEPT the following cycles: \[1\] Cycle 1, \[2\] the last cycle of neoadjuvant therapy immediately preceding ICS, and \[3\] the first cycle of adjuvant chemotherapy (i.e., first cycle after ICS). During the maintenance phase, BEV 15 mg/kg will be administered every 3 weeks as a single agent until disease progression or unacceptable toxicity for a maximum of an additional 18 cycles. In total, BEV may be administered up to 24 cycles. FDA approved BEV biosimilars may be used in this study in place of BEV.
IMNN-001
IL-12 Plasmid Formulated with PEG-PEI-Cholesterol Lipopolymer
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Johns Hopkins Medicine SKCCC, Baltimore
RECRUITING
OU Health, Stephenson Cancer Center, Oklahoma City
RECRUITING
University of Texas MD Anderson Cancer Center, Houston
Lead Sponsor
Breakthrough Cancer Research
UNKNOWN
Imunon
INDUSTRY