First-in-human Dose Escalation and Expansion Study With the SIRPα-directed Monoclonal Antibody BYON4228

PHASE1RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

March 4, 2024

Primary Completion Date

October 1, 2025

Study Completion Date

December 1, 2025

Conditions
Lymphoma
Interventions
DRUG

BYON4228 + Rituximab

"BYON4228 is a humanized monoclonal antibody (mAb) directed against SIRPα. BYON4228 IV infusion every four weeks until disease progression or unacceptable toxicity. Different doses.~Rituximab IV infusion (375 mg/m2) starting from the second treatment cycle onwards. Weekly infusion during the first cycle and every four weeks in subsequent 5 cycles."

Trial Locations (12)

Unknown

RECRUITING

ASST Spedali Civili di Brescia, Brescia

RECRUITING

Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia - IRCCS, Candiolo

RECRUITING

Instituto Europeo di Oncologia, Milan

RECRUITING

IRCCS Ospedale San Raffaele, Milan

RECRUITING

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRCCS IRST, Ravenna

RECRUITING

Vrije Universiteit Medisch Centrum, Amsterdam

RECRUITING

Radboud UMC, Nijmegen

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

RECRUITING

Institut Català d'Oncologia, Barcelona

RECRUITING

Centro Integral Oncológico Clara Campal (CIOCC) Hospital Universitario HM Sanchinarro, Madrid

RECRUITING

The Christie NHS Foundation Trust, Manchester

RECRUITING

University Hospitals Plymouth NHS Trust, Plymouth

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Byondis B.V.

INDUSTRY