PD-1 Antibody Combined With mXELIRI Versus mXELIRI in the Second-line Setting for ESCC

PHASE3RecruitingINTERVENTIONAL
Enrollment

380

Participants

Timeline

Start Date

February 17, 2023

Primary Completion Date

February 17, 2026

Study Completion Date

February 17, 2026

Conditions
Esophageal Squamous Cell Carcinoma Abdominal Stage 0
Interventions
DRUG

PD-1 Inhibitors

Teripulimab 240mg, injection or Carrelizumab 200mg, injection, every 3 weeks.

DRUG

Irinotecan

Irinotecan: 200mg/m2, injection (For patients who are confirmed to be homozygous for UGT1A1\*6 or UGT1A1\*28 or UGT1A1\*6 and UGT1A1\*28 at the same time, the starting dose of CPT-11 is 150 mg/m2).

DRUG

Capecitabine tablets

Capecitabine: 1600 mg/m2/d, oral, 2 weeks on and 1 week off.

Trial Locations (1)

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
collaborator

Shanghai Junshi Bioscience Co., Ltd.

OTHER

collaborator

Jiangsu HengRui Medicine Co., Ltd.

INDUSTRY

lead

Sun Yat-sen University

OTHER