A Study of Selinexor in Combination With Azacitidine and Venetoclax (SAV Regimen) in Treatment Naïve Participants With Acute Myeloid Leukemia

PHASE2RecruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

February 20, 2023

Primary Completion Date

March 30, 2025

Study Completion Date

April 30, 2027

Conditions
AML, Adult
Interventions
DRUG

Selinexor

Selinexor 60mg, PO d3,10,17

DRUG

Azacitidine

Azacitidine 75mg/m2, IV d1-3, 8-9, 15-16

DRUG

Venetoclax

Venetoclax 100mg PO on day 1 and 200mg on day 2, 400mg on day 3-14

Trial Locations (19)

Unknown

NOT_YET_RECRUITING

Changzhou Municipal No.1 People's Hospital, Changzhou

NOT_YET_RECRUITING

Sichuan Provincial People's Hospital, Chengdu

NOT_YET_RECRUITING

Jilin University China Japan Union Hospital, Ch’ang-ch’un

NOT_YET_RECRUITING

Harbin Institute of Hematology and Oncology, Ha’erbin

NOT_YET_RECRUITING

Anhui Provincial Hospital, Hefei

NOT_YET_RECRUITING

the first hospital of Jiaxing affiliated hospital of Jiaxing University, Jiaxing

NOT_YET_RECRUITING

Gansu Provincial People's Hospital, Lanzhou

NOT_YET_RECRUITING

Lanzhou University NO.2 Hospital, Lanzhou

NOT_YET_RECRUITING

Ningbo Medical Center Lihuili Huspital, Ningbo

NOT_YET_RECRUITING

Shanghai Ruijin Hospital, Shanghai

RECRUITING

Shanghai Tong Ren hospital, Shanghai

NOT_YET_RECRUITING

The First Hospital of China Medical University, Shenyang

NOT_YET_RECRUITING

The First Hospital of Hebei Medical University, Shijia Zhuang

NOT_YET_RECRUITING

The Second Hospital of Hebei Medical University, Shijia Zhuang

NOT_YET_RECRUITING

First Affiliated Hospital of Xinjiang Medical University, Ürümqi

NOT_YET_RECRUITING

the Second Affiliated Hospital of Wannan Medical College, Wuhu

NOT_YET_RECRUITING

Xi'an International Medical Center, Xi'an

NOT_YET_RECRUITING

Northern Jiangsu People's Hospital, Yangzhou

NOT_YET_RECRUITING

Yixing People's Hospital, Yixing

All Listed Sponsors
lead

Shanghai Tong Ren Hospital

OTHER