NCT05736406 - A Dose-escalation Clinical Study of Intraoperative Photodynamic Therapy of Glioblastoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

February 20, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

July 31, 2026

Conditions

Primary Glioblastoma

Interventions

COMBINATION_PRODUCT

5-ALA HCl intraoperative Photodynamic Therapy (PDT) at 200 J/cm^2

5-ALA HCl, 20 mg/kg, is orally administered 4-6 hours before the surgery. Then after resection of tumor tissue is judged maximal, the intraoperative PDT procedure is initiated at 200 J/cm\^2.

COMBINATION_PRODUCT

5-ALA HCl intraoperative Photodynamic Therapy (PDT) at 400 J/cm^2

5-ALA HCl, 20 mg/kg, is orally administered 4-6 hours before the surgery. Then after resection of tumor tissue is judged maximal, the intraoperative PDT procedure is initiated at 400 J/cm\^2.

Trial Locations (2)

15213

RECRUITING

UPMC Hillman Cancer center, Pittsburgh

59037

RECRUITING

CHU De Lille, Hôpital Roger Salengro, Lille