A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

PHASE1RecruitingINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

July 18, 2023

Primary Completion Date

April 30, 2030

Study Completion Date

April 30, 2030

Conditions
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AMLAML With Mutated NPM1Acute Myeloid Leukemia RecurrentAcute Myeloid Leukemia, in RelapseNPM1 MutationKMT2ArMyeloid SarcomaNucleophosmin 1-mutated Acute Myeloid Leukemia
Interventions
DRUG

Ziftomenib

Oral Administration

DRUG

Venetoclax

Oral Administration

DRUG

Azacitidine

Subcutaneous or Intravenous Administration

DRUG

Daunorubicin

Intravenous Administration

DRUG

Cytarabine

Intravenous Administration

DRUG

Quizartinib

Oral Administration

Trial Locations (44)

10021

RECRUITING

New York - Presbyterian / Weill Cornell Medicine, New York

10029

RECRUITING

Mount Sinai - Ruttenberg Treatment Center, New York

10032

RECRUITING

Columbia University Medical Center, New York

11794

RECRUITING

Stony Brook University Hospital, Stony Brook

14203

RECRUITING

Roswell Park Comprehensive Cancer Center, Buffalo

19104

RECRUITING

Hospital of the University of Pennsylvania, Philadelphia

21205

RECRUITING

Johns Hopkins School of Medicine, Baltimore

27705

RECRUITING

Duke Blood Cancer Center, Durham

30308

RECRUITING

Emory Healthcare - The Emory Clinic, Atlanta

30912

RECRUITING

Georgia Cancer Center at Augusta University, Augusta

32224

RECRUITING

Mayo Clinic Jacksonville, Jacksonville

37203

RECRUITING

TriStar Bone Marrow Transplant, Nashville

40202

RECRUITING

University of Kentucky Markey Cancer Center, Louisville

40207

RECRUITING

Norton Cancer Institute - St. Matthews, Louisville

43210

RECRUITING

The James Cancer Hospital and Solove Research Institute, Columbus

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

44195

RECRUITING

Cleveland Clinic Taussig Cancer Institute, Cleveland

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

RECRUITING

Karmanos Cancer Institute, Detroit

52242

RECRUITING

University of Iowa Hospitals & Clinics, Iowa City

53226

RECRUITING

Medical College of Wisconsin Cancer Center, Milwaukee

53792

RECRUITING

University of Wisconsin Hospital and Clinics, Madison

55455

RECRUITING

University of Minnesota, Minneapolis

55905

RECRUITING

Mayo Clinic - Rochester, Rochester

60153

RECRUITING

Loyola University Medical Center, Maywood

60611

RECRUITING

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

66205

RECRUITING

The University of Kansas Medical Center Research Institute, Fairway

70121

RECRUITING

Ochsner MD Anderson Cancer Center, Jefferson

73104

RECRUITING

OU Health Stephenson Cancer Center, Oklahoma City

75235

RECRUITING

UT Southwestern - Simmons Cancer Center, Dallas

77030

RECRUITING

MD Anderson Cancer Center, Houston

78704

RECRUITING

Sarah Cannon Research Institute - St. David's South Austin Medical Center / Texas Oncology South Austin, Austin

80045

RECRUITING

University of Colorado, Aurora

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

85054

RECRUITING

Mayo Clinic - Phoenix, Phoenix

90033

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

90095

RECRUITING

UCLA - Bowyer Oncology Center, Los Angeles

92093

RECRUITING

Moores UC San Diego Cancer Center, La Jolla

92868

RECRUITING

UC Irvine Health Chao Family Comprehensive Cancer Center, Orange

06510

RECRUITING

Yale Cancer Center and Smilow Cancer Hospital, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

01655

RECRUITING

UMass Chan Medical School, Worcester

07601

RECRUITING

Hackensack University Medical Center, Hackensack

08903

RECRUITING

Rutgers Cancer Institute, New Brunswick

Sponsors
All Listed Sponsors
lead

Kura Oncology, Inc.

INDUSTRY