Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial)

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 27, 2025

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2026

Conditions
Gastroesophageal Adenocarcinoma
Interventions
COMBINATION_PRODUCT

FLOT

"* Oxaliplatin 85 mg/m2 IV on Day 1~* Docetaxel 50 mg/m2 IV on Day 1~* Leucovorin 200 mg/m2 IV on Day 1~* Fluorouracil 2600 mg/m2 continuous infusion over 24 hours daily on Day 1 Every 14 Days"

COMBINATION_PRODUCT

FOLFOX

"* Oxaliplatin 85 mg/m2 IV on Day 1~* Leucovorin 400 mg/m2 IV on Day 1~* Fluorouracil 400 mg/m2 IV Push on Day 1~* Fluorouracil 1200 mg/m2 continuous infusion over 24 hours daily on Days 1 and 2 Every 14 Days"

COMBINATION_PRODUCT

FOLFIRI

"* Irinotecan 180 mg/m2 IV on Day 1~* Leucovorin 400 mg/m2 IV on Day 1~* Fluorouracil 400 mg/m2 IV Push on Day 1~* Fluorouracil 1200 mg/m2 continuous infusion over 24 hours daily on Days 1 and 2 Every 14 Days"

COMBINATION_PRODUCT

FOLFIRINOX

"* Oxaliplatin 85 mg/m2 IV on Day 1~* Irinotecan 150 mg/m2 IV on Day 1~* Leucovorin 200 mg/m2 IV on Day 1~* Fluorouracil 1200 mg/m2 continuous infusion over 24 hours daily on Days 1 and 2 Every 14 days"

COMBINATION_PRODUCT

PACLITAXEL with or without CARBOPLATIN

"* Paclitaxel 200 mg/m2 IV on Day 1~* Carboplatin AUC 5 IV on day 1 Every 21 Days~OR~\- Paclitaxel 80mg/m2 IV on Days 1,8,15 Every 28 Days"

COMBINATION_PRODUCT

DOCETAXEL and IRINOTECAN (alone or combined)

"* Docetaxel 35 mg/m2 IV on Days 1 and 8~* Irinotecan 50 mg/m2 IV on Days 1 and 8 Every 21 Days~* Docetaxel 75 mg/m2 IV on Day 1 Every 21 Days~* Docetaxel 150 mg/m2 IV on Day 1 Every 14 Days"

DRUG

NIVOLUMAB (alone or when added to a regimen above)

"* 240 mg IV on Day 1 every 14 days, or~* 360 mg IV on Day 1 every 21 days, or~* 480 mg IV on Day 1 every 28 days"

DRUG

PEMBROLIZUMAB (alone or when added to a regimen above)

"* 200 mg IV on Day 1 every 21 days, or~* 400 mg IV on Day 1 every 42 days"

DRUG

Durvalumab

\- 1500 mg IV on Day 1 every 28 days

DRUG

Trastuzumab

"* 8 mg/kg on Day 1, then 6 mg/kg IV every 21 days, or~* 6 mg/kg on Day 1, then 4 mg/kg IV every 14 days"

Trial Locations (1)

92868

RECRUITING

Chao Family Comprehensive Cancer Center, University, Orange

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

BillionToOne, Inc

UNKNOWN

lead

University of California, Irvine

OTHER

NCT05733689 - Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial) | Biotech Hunter | Biotech Hunter