23
Participants
Start Date
May 9, 2023
Primary Completion Date
December 1, 2023
Study Completion Date
December 1, 2023
Alpelisib 150 mg [Piqray], 2 overencapsulated tablets (total: 300 mg)
Participants will ingest two overencapsulated tablets of alpelisib at 23:00, along with a saltine cracker.
Placebo (microcrystalline cellulose), 2 capsules
Participants will ingest two capsules filled with microcrystalline cellulose at 23:00, along with a saltine cracker.
FreeStyle Libre Pro
Continuous glucose monitoring for 24 hours (double blinded)
Oral glucose tolerance test (OGTT) with Trutol glucose beverage
Participants will drink Trutol glucose beverage (D-glucose 75 g in 10 fl oz) and blood will be sampled at baseline and at 15, 30, 60, 90, 120, 150, and 180 minutes.
BOOST Plus nutritional beverage
Participants will consume a quantity of BOOST Plus calculated to match their daily caloric needs, divided over three liquid meals.
Columbia University Irving Medical Center, New York
Columbia University
OTHER