Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

225

Participants

Timeline

Start Date

May 26, 2023

Primary Completion Date

May 31, 2026

Study Completion Date

September 30, 2026

Conditions
Locally Advanced Solid Tumor
Interventions
DRUG

TNG462

TNG462, a selective PRMT5 inhibitor, will be administered orally

DRUG

Pembrolizumab

An anti PD-1 antibody, will be administered intravenously

Trial Locations (25)

10016

RECRUITING

New York University Langone Health, New York

22031

RECRUITING

Next Oncology Virginia, Fairfax

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28050

RECRUITING

Hospital de Sanchinarro, Madrid

29010

RECRUITING

Hospital Universitario Virgen de la Victoria, Málaga

29200

RECRUITING

CHU de Brest, Brest

33136

RECRUITING

Sylvester Comprehensive Cancer Center, Miami

37203

RECRUITING

Sarah Cannon Tennessee Oncology, Nashville

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

44805

RECRUITING

Institut de Cancerologie de l'Ouest - Hôpital Saint Herblain - PPDS, Saint-Herblain

48202

RECRUITING

Henry Ford Cancer Center, Detroit

60099

RECRUITING

Midwestern Regional Medical Center, City of Hope Chicago, Zion

60637

RECRUITING

University Chicago Medicine, Chicago

61801

RECRUITING

Carle Cancer Center, Urbana

69373

RECRUITING

Centre Berard Leon, Lyon

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

81505

RECRUITING

Grand Valley Oncology, Grand Junction

84112

RECRUITING

Huntsman Cancer Institute, University of Utah, Salt Lake City

94304

RECRUITING

Stanford University, Palo Alto

94805

RECRUITING

Institute Gustav Roussy, Villejuif

02214

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Dana Farber Cancer Institute, Boston

Unknown

RECRUITING

Vall d'Hebron Barcelona Hospital, Barcelona

08023

RECRUITING

Hospital HM Nou Delfos, Barcelona

08908

RECRUITING

ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona

All Listed Sponsors
lead

Tango Therapeutics, Inc.

INDUSTRY