670
Participants
Start Date
March 30, 2023
Primary Completion Date
March 1, 2028
Study Completion Date
March 1, 2030
Lifileucel plus Pembrolizumab
A tumor sample is resected from each patient for Lifileucel manufacturing. Patients then receive Pembrolizumab followed by the lifileucel regimen which consists of non-myeloablative lymphodepletion, lifileucel infusion followed by IL-2. Patients will then continue to receive Pembrolizumab every 6 weeks until disease progression.
Pembrolizumab with Optional Crossover Period
"Patient will receive Pembrolizumab monotherapy every 6 weeks until disease progression. Upon verified confirmed disease progression by the blinded independent review central committee, patients may proceed to lifileucel monotherapy during an optional crossover period if they meet eligibility criteria.~Optional crossover: A tumor sample is resected from each patient for Lifileucel manufacturing. Patients then receive the lifileucel regimen which consists of non-myeloablative lymphodepletion, lifileucel infusion followed by IL-2."
RECRUITING
Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne
RECRUITING
Universitätsklinikum Carl Gustav Carus, Dresden
RECRUITING
Peter MacCallum Cancer Centre, Melbourne
RECRUITING
Seoul National University Hospital, Seoul
RECRUITING
Severance Hospital, Yonsei University Health System, Seoul
RECRUITING
Greenslopes Private Hospital, Greenslopes
RECRUITING
Flinders Medical Centre, Bedford Park
RECRUITING
Fiona Stanley Hospital, Murdoch
RECRUITING
Hospital Clinic de Barcelona, Barcelona
RECRUITING
ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona
RECRUITING
Institut Paoli Calmettes, Marseille
RECRUITING
Allegheny Health Network, Pittsburgh
RECRUITING
St. Luke's Cancer Center - Anderson, Easton
RECRUITING
Istituto Europeo Di Oncologia, Milan
RECRUITING
Universitätsklinikum Hamburg-Eppendorf, Hamburg
RECRUITING
National Cancer Institute, Bethesda
RECRUITING
Virginia Commonwealth University, Richmond
RECRUITING
Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck
RECRUITING
Hospital General Universitario Gregorio Maranon, Madrid
RECRUITING
Hospital 12 de Octubre, Madrid
RECRUITING
Hospital Universitario Madrid Sanchinarro - CIOCC, Madrid
RECRUITING
Hospital Universitario Quirónsalud Madrid, Madrid
RECRUITING
Hospital Regional Universitario de Malaga - Hospital General, Málaga
RECRUITING
Clínica Universitaria de Navarra, Pamplona
RECRUITING
Orlando Health Cancer Institute, Orlando
RECRUITING
Centro di Riferimento Oncologico IRCCS, Aviano
RECRUITING
University of Alabama at Birmingham: The Kirklin Clinic, Birmingham
RECRUITING
SCRI Oncology Partners, Nashville
RECRUITING
Baptist Cancer Center, Bartlett
RECRUITING
Hospital Universitario Marques de Valdecilla, Santander
RECRUITING
University of Louisville - James Graham Brown Cancer Center, Louisville
RECRUITING
Hospital Universitario Virgen Macarena, Seville
RECRUITING
Ohio State University, Columbus
RECRUITING
Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu, Nantes
RECRUITING
Oncology Hematology Care, Cincinnati
RECRUITING
Consorcio Hospital General Universitario de Valencia, Valencia
RECRUITING
Istituto Romagnolo per lo Studio dei Tumori, Meldola
RECRUITING
Barbara Ann Karmanos Cancer Hospital dba Karmanos Cancer Center, Detroit
RECRUITING
Henry Ford Health, Detroit
RECRUITING
Sheba Medical Center, Ramat Gan
RECRUITING
Azienda Ospedaliero Universitaria Pisana, Pisa
RECRUITING
University of Illinois Hospital & Health Sciences System, Chicago
RECRUITING
University of Kansas, Kansas City
RECRUITING
Hopital Saint Louis, Paris
RECRUITING
University of Colorado Cancer Center, Aurora
RECRUITING
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale, Napoli
RECRUITING
Klinikum Rechts der Isar der Technischen Universität München, Munich
RECRUITING
USC Norris Comprehensive Cancer Center, Los Angeles
RECRUITING
City of Hope, Duarte
RECRUITING
California Pacific Medical Center, San Francisco
RECRUITING
Swedish Cancer Institute, Edmonds
RECRUITING
Tel Aviv Sourasky Medical Center, Tel Aviv
RECRUITING
Dartmouth-Hitchcock Medical Center (DHMC) - Norris Cotton Cancer Center, Lebanon
RECRUITING
MD Anderson Cancer Center at Cooper, Camden
RECRUITING
Westmead Hospital, Westmead
RECRUITING
Universitair Ziekenhuis Brussel - Oncologisch Centrum, Jette
RECRUITING
Hadassah Medical Center, Jerusalem
RECRUITING
Azienda Ospedaliera Universitaria Senese, Siena
RECRUITING
Bundang Medical Center - CHA University, Seongnam-si
RECRUITING
Hospital Universitario Ramon y Cajal, Madrid
RECRUITING
Centre hospitalier de l'Université de Montréal, Montreal
RECRUITING
Princess Margaret Cancer Centre, Toronto
RECRUITING
Nederlands Kanker Instituut, Amsterdam
RECRUITING
Instituto Oncologico Rosell, Barcelona
RECRUITING
Hospital Universitari Vall dHebron, Barcelona
RECRUITING
Sahlgrenska Universitetssjukhuset, Gothenburg
RECRUITING
Queen Elizabeth Hospital Birmingham, Birmingham
RECRUITING
Freeman Hospital, Newcastle upon Tyne
RECRUITING
Royal Marsden Hospital, Chelsea
RECRUITING
Beaston West of Scotland Canter Centre, Glasgow
RECRUITING
Guy's Hospital, London
RECRUITING
Sarah Cannon Research Institute UK, London
Lead Sponsor
Iovance Biotherapeutics, Inc.
INDUSTRY