Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

October 31, 2023

Primary Completion Date

November 1, 2027

Study Completion Date

November 1, 2027

Conditions
Tobacco Use Disorder
Interventions
DEVICE

active repetitive transcranial magnetic stimulation

Active rTMS is a non-invasive brain stimulation intervention that is FDA cleared as a treatment for smoking cessation in adults.

DEVICE

sham repetitive transcranial magnetic stimulation

Sham rTMS involves no brain stimulation, but appears to the participant and provider to be active rTMS.

BEHAVIORAL

cognitive behavioral therapy for smoking cessation

All participants will receive five sessions of cognitive behavioral therapy (CBT) for smoking cessation.

DRUG

nicotine replacement therapy

"All participants will receive nicotine replacement therapy in for the form of 21 mg, 14 mg, and/or 7 mg nicotine patches (based on smoking quantity) and a rescue method such as nicotine lozenge or nicotine gum."

Trial Locations (1)

27705-3875

RECRUITING

Durham VA Medical Center, Durham, NC, Durham

All Listed Sponsors
lead

VA Office of Research and Development

FED