STOP-HER2: Stopping Trastuzumab in HER2+ MBC

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

April 19, 2023

Primary Completion Date

February 28, 2026

Study Completion Date

February 29, 2036

Conditions
Breast CancerMetastatic Breast CancerHER2-positive Breast Cancer
Interventions
OTHER

Cessation of anti-HER2 treatment

Cessation of anti-HER2 treatment with standard treatment described as trastuzumab (Herceptin) with or without pertuzumab (Perjeta) continued as long as it is working or significant side effects occur.

Trial Locations (13)

15213

University of Pittsburgh Medical Center, Pittsburgh

27710

Duke University, Durham

32224

Mayo Clinical Hospital Florida, Jacksonville

55905

Mayo Clinic Rochester, Rochester

77030

Baylor College of Medicine, Houston

85054

Mayo Clinic Hospital Arizona, Phoenix

98109

Fred Hutchinson Cancer Center, Seattle

02809

Georgetown University Medical Center, Washington D.C.

02215

Dana-Farber Cancer Insitute, Boston

02035

DFCI @ Foxborough, Foxborough

01844

DFCI @ Merrimack Valley, Methuen

01757

DFCI @ Milford Regional Hospital, Milford

02190

DFCI @ South Shore Hospital, South Weymouth

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Gateway for Cancer Research

OTHER

collaborator

Susan G. Komen Breast Cancer Foundation

OTHER

collaborator

Translational Breast Cancer Research Consortium

OTHER

collaborator

Johns Hopkins University

OTHER

lead

Dana-Farber Cancer Institute

OTHER