Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection

PHASE4CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

December 6, 2022

Primary Completion Date

June 8, 2023

Study Completion Date

June 8, 2023

Conditions
Overactive BladderOveractive Bladder SyndromeUrge IncontinenceUrinary Incontinence, Urge
Interventions
DRUG

Single-Dose Antibiotic

"Allergy, prior urine culture resistance or another contraindication to first line antibiotic will result in the patient being prescribed second line antibiotic and so forth.~First line:~Arm 1: trimethoprim / sulfamethoxazole 800/160 mg once pre-procedure~Second line:~Arm 1: cefalexin 500 mg once pre-procedure~Third line:~Arm 1: nitrofurantoin 100 mg once pre-procedure~Fourth line:~Arm 1: ciprofloxacin 500 mg once pre-procedure"

DRUG

Multi-Dose Antibiotic

"Allergy, prior urine culture resistance or another contraindication to first line antibiotic will result in the patient being prescribed second line antibiotic and so forth.~First line:~Arm 2: trimethoprim / sulfamethoxazole 800/160 mg once pre-procedure plus 800/160 mg every twelve hours for 6 total doses~Second line:~Arm 2: cefalexin 500 mg once pre-procedure plus 500 mg every twelve hours for 6 total doses~Third line:~Arm 2: nitrofurantoin 100 mg once pre-procedure plus 100 mg every twelve hours for 6 total doses~Fourth line:~Arm 2: ciprofloxacin 500 mg once pre-procedure plus 500 mg every twelve hours for 6 total doses"

Trial Locations (1)

44195

Cleveland Clinic Foundation, Cleveland

All Listed Sponsors
lead

The Cleveland Clinic

OTHER