Effect of a Personalized Weaning Strategy on Weaning Success

NARecruitingINTERVENTIONAL
Enrollment

750

Participants

Timeline

Start Date

March 14, 2023

Primary Completion Date

March 23, 2026

Study Completion Date

March 23, 2026

Conditions
WeaningMechanical VentilationIntubation
Interventions
OTHER

Standard SBT

Weaning strategy in accordance with the care practices of the department, regarding the assessment of weaning criteria, SBT and extubation modalities.

OTHER

SBT with T-piece or PSV

"\- Risk factors of WIPO~Step 1 : Daily assessment of weaning criteria in accordance with the study protocol.~Step 2 : Spontaneous breathing trial with T-piece for an hour. Measure of protein and haemoglobin by blood sample before and after the trial.~Step 3 : Reconnect the patient to the ventilator for at least 30 minutes and then extubate if SBT is successful.~If SBT failed : no extubation and new SBT the next day. Optimization of cardiac function or fluid overload will be in charge of the investigator.~\- No risk factors of WIPO~Step 1 : Daily assessment of weaning criteria in accordance with the study protocol.~Step 2 : Spontaneous breathing trial with pressure support ventilation (pressure support from 5 to 8 cmH20 - PEEP at 0 cmH20) for an hour.~Step 3 : Reconnect the patient to the ventilator for at least 30 minutes and then extubate if SBT is successful."

Trial Locations (9)

Unknown

RECRUITING

CHU de Bordeaux, Bordeaux

RECRUITING

CHU de Clermont-Ferrand, Clermont-Ferrand

RECRUITING

CHU de Grenoble, Grenoble

RECRUITING

CHU de Lille, Lille

RECRUITING

CHU de Lyon - Hôpital Lyon Sud, Lyon

RECRUITING

CHU de Montpellier, Montpellier

RECRUITING

CHU de Nantes, Nantes

RECRUITING

CHU de Saint-Etienne, Saint-Etienne

RECRUITING

CHU de Toulouse, Toulouse

All Listed Sponsors
lead

University Hospital, Clermont-Ferrand

OTHER

NCT05719194 - Effect of a Personalized Weaning Strategy on Weaning Success | Biotech Hunter | Biotech Hunter