Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

February 6, 2024

Primary Completion Date

May 3, 2026

Study Completion Date

May 3, 2026

Conditions
Metastatic Dedifferentiated LiposarcomaMetastatic LeiomyosarcomaMetastatic MyxofibrosarcomaMetastatic SarcomaMetastatic Synovial SarcomaMetastatic Undifferentiated Pleomorphic SarcomaUnresectable Dedifferentiated LiposarcomaUnresectable LeiomyosarcomaUnresectable MyxofibrosarcomaUnresectable SarcomaUnresectable Synovial SarcomaUnresectable Undifferentiated Pleomorphic Sarcoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood and tissue sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Pegylated Liposomal Doxorubicin Hydrochloride

Given IV

DRUG

Peposertib

Given PO

Trial Locations (16)

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20892

RECRUITING

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

48109

SUSPENDED

University of Michigan Comprehensive Cancer Center, Ann Arbor

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

77030

RECRUITING

M D Anderson Cancer Center, Houston

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH