A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)

PHASE1/PHASE2UnknownINTERVENTIONAL
Enrollment

314

Participants

Timeline

Start Date

March 3, 2023

Primary Completion Date

June 30, 2024

Study Completion Date

December 31, 2024

Conditions
CancerSolid TumorMelanomaCarcinomaSarcomaLung CancerProstate CancerBreast CancerColo-rectal CancerUterine CancerPancreatic CancerGastric CancerEsophageal CancerThyroid CancerOvarian CancerKidney CancerHead and Neck Cancer
Interventions
DRUG

KVA12123 - Dose Escalation

Ascending KVA12123 doses given as monotherapy by intravenous administration every 2 weeks of each 6-week cycle.

DRUG

KVA12123 Plus Pembrolizumab - Dose Escalation

Ascending KVA12123 doses given by intravenous administration every 2 weeks of each 6-week cycle in combination with a fixed dose of pembrolizumab administered once every 6 week cycle.

DRUG

KVA12123 - Dose Expansion

KVA12123 administered at the RP2D by intravenous administration every 2 weeks of each 6 week cycle.

DRUG

KVA12123 Plus Pembrolizumab - Dose Expansion

KVA12123 administered at the RP2D by intravenous administration every 2 weeks in combination with a fixed dose of pembrolizumab administered once every 6 week cycle.

Trial Locations (6)

19107

RECRUITING

Thomas Jefferson University, Philadelphia

34232

RECRUITING

Sarah Cannon Research Institute at Florida Cancer Specialists, Sarasota

37203

RECRUITING

Sarah Cannon Research Institute at Tennessee Oncology, Nashville

48109

RECRUITING

University of Michigan, Ann Arbor

80218

RECRUITING

Sarah Cannon Research Institute at HealthONE, Denver

90404

RECRUITING

UCLA Health (Santa Monica Cancer Care), Santa Monica

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Kineta Inc.

INDUSTRY