CMV Immunity Monitoring in Lung Transplant Recipients

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

September 13, 2024

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2026

Conditions
Lung Transplant; Complications
Interventions
DEVICE

Cytomegalovirus T Cell Immunity Panel (CMV-TCIP)

Whole blood assay that evaluates T cell (CD4 and CD8) responses to cytomegalovirus (CMV) antigens via intracellular cytokine staining (ICS).

DIAGNOSTIC_TEST

Donor-Derived Cell-Free DNA (dd-cfDNA) Assay

Determines the percentage of circulating cell-free DNA (cfDNA) in transplant recipients derived from donor grafts.

DRUG

Valganciclovir

Delivered as standard of care for post-lung transplant immunosuppression and infection prophylaxis. Started on the first day post-transplant at a standard dose of 900 mg daily and continued for 12 months. Dose adjustments may be necessary based on renal function and/or adverse effects (e.g. neutropenia). Dose adjustments are standard based on package insert recommendations.

Trial Locations (1)

10016

RECRUITING

NYU Langone Health, New York

All Listed Sponsors
collaborator

Viracor Eurofins

UNKNOWN

lead

NYU Langone Health

OTHER