15
Participants
Start Date
February 1, 2023
Primary Completion Date
May 17, 2024
Study Completion Date
May 17, 2024
Nicotine vaping visit 1 (free-base nicotine)
Participants will receive the free-base form of four nicotine fluxes: 9, 18, 27, 35 μg/sec at one of their two visits. Participants will use the ENDS device with free-base nicotine and four fluxes in random order.
Nicotine vaping visit 1 (protonated nicotine)
Participants will receive the protonated form of four nicotine fluxes: 9, 18, 27, 35 μg/sec at the other study visit. Participants will use the ENDS device with protonated nicotine and four fluxes in random order.
Nicotine vaping visit 2 (free-base nicotine)
Participants who received protonated nicotine during visit 1 will now receive free-base nicotine fluxes for visit 2: 9, 18, 27, 35 μg/sec.
Nicotine vaping visit 2 (protonated nicotine)
Participants who received free-base nicotine during visit 1 will now receive protonated nicotine fluxes for visit 2: 9, 18, 27, 35 μg/sec.
Human Research Unit (HRU), New Haven
American University of Beirut Medical Center
OTHER
National Institute on Drug Abuse (NIDA)
NIH
Yale University
OTHER